The show will be filmed in the week that the Liberal Democrat party conference is held in the town.
To be in the audience – and in with a chance to ask a question – call 0330 123 9988 or click here.
Earlier this year the Telegraph criticised Question Time for featuring her so often. She has been on the panel eight times in just over three years.
The show was last broadcast from Brighton in October 2009 to coincide with the Labour Party conference. David Dimbleby chaired proceedings at St Bartholomew’s Church.
His guests were Ben Bradshaw, who was then the Labour Culture Secretary, Theresa May for the Conservatives and the former Lib Dem leader Charles Kennedy.
Also on the panel were the historian David Starkey and the economist Dambisa Moyo, who Time magazine described as one of the 100 most influential people in the world.
She accused him of being a racist, “playing xenophobia for laughs” with comments that he made about the Rochdale “grooming” case – an accusation that he denied.