Chris Hughton makes wholesale changes to his starting line up as Bruno, Pascal Gross and Ali Jahanbakash all make the starting eleven.
Yves Bissouma and Martin Montoya are dropped from the squad after the 5-0 thrashing by Bournemouth on Saturday (13 April).
Glenn Murray again leads the line for Albion up front as both Jurgen Locadia and Florin Andone drop to the bench.
This is a must win game for the Seagulls. A victory would all but secure Premier League survival.