Firefighters have been tackling a blaze at the Dean Wood care home in Warren Road, Woodingdean.
Residents were reported to have been evacuated to the neighbouring Nuffield Hospital.
Shortly before 5pm, East Sussex Fire and Rescue Service said that fire was out at the BUPA-run home, with smoke having earlier been visible for some distance.
The fire service said: “We were called at 3.18pm on Wednesday 30 August to reports of a fire at a property in Warren Road, Woodingdean, Brighton.
“There are five fire engines with crews from Roedean, Preston Circus, Hove and Lewes in attendance, along with an aerial ladder platform and incident control unit.
“The aerial ladder platform, one main jet and one hydrant are currently in use.
“Please avoid the area.”
The fire service added: “Crews dealt with the incident quickly and as of 4.09pm the fire had been extinguished.
“Crews reported the fire was affecting solar panels on the roof of a nursing home.
“A full evacuation was completed and there were no reports of casualties.”
Sussex Police, the South East Coast Ambulance Service (Secamb) and Brighton and Hove City Council were also in attendance.
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