Three babies are being treated for blood poisoning at the Royal Sussex County Hospital in Brighton.
They are believed to have contracted septicaemia from infected saline drips and an investigation is under way, according to Public Health England.
The three newborns are among 15 babies to have suffered blood poisoning from the same batch of drips.
One baby has died in London at one of the other five hospitals affected by the incident.
The three in Brighton are reported to be recovering.
Public Health England is investigating along with the Medicines and Healthcare products Regulatory Agency.
Public Health England said: “PHE and the MHRA are investigating 15 cases of blood poisoning (septicaemia) caused by a bacteria known as ‘bacillus cereus’.
“The affected babies were in neonatal intensive care units at a small number of hospitals in England.
“Many of the babies were premature and very vulnerable and one baby has sadly died but the others are responding to antibiotic treatment.
“Investigations are ongoing but so far indications show that the cases have been strongly linked with a number of batches of a particular form of intravenous liquid called parenteral nutrition which was given to the babies.
“This contains a variety of nutrients that are delivered directly into the babies’ bloodstream when they have problems ingesting food via their mouth.
“This batch of product is manufactured by ITH Pharma Limited.
“Because this type of nutrition is given into the bloodstream of vulnerable babies and adults it is manufactured under strictly controlled aseptic conditions.
“Investigations with the company have identified an incident that might have caused the contamination.
“Investigations into this by the MHRA are ongoing and inspectors from the MHRA are visiting the manufacturing plant.
“The product has a short shelf life and although it is unlikely that any stock from the day of contamination incident remains (it expired on 2 June 2014) the MHRA has issued a class 1 drug alert to support the manufacturer’s recall of the product.
